Hydrochloric Acid → 2-methoxy-5-(5-trifluoromethyl-1H-tetrazol-1-yl)benzoic acid

Participants

Reaction Steps

Combine methyl 2-methoxy-5-(5-trifluoromethyl-1H-tetrazol-1-yl)benzoate (1.46 g, 5.27 mmol) and an aqueous solution of sodium hydroxide (20 mL, 2 M, 40 mmol) in methanol/tetrahydrofuran (20 mL/10 mL). After 2 hours, adjust the pH of the reaction mixture to about 2 using a 1 M aqueous hydrochloric acid solution. Extract the reaction mixture with ethyl acetate and then dichloromethane. Dry the combined organic layers over MgSO4, filter, and evaporate in vacuo to give a the title compound: Rf=0.55 (silica gel, 85% chloroform/10% methanol/5% acetic acid).

Provenance & Evidence