2-Methylsulfinyl-5-(1H-tetrazol-1-yl)benzoic Acid → 1-(2-methylsulfinyl-5-(1H-tetrazol-1-yl)benzoyl)-3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-phenylpyrrolidine

HRID 323388Notes

Reaction equation

HRID 323388 reaction equation
Cl.[CH2:2]([O:4][CH2:5][CH2:6][N:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[N:9]=[C:8]1[NH:16][CH:17]1[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][C:25]2([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH2:29][CH2:28][NH:27][CH2:26]2)[CH2:19][CH2:18]1)[CH3:3].[CH3:36][S:37]([C:39]1[CH:47]=[CH:46][C:45]([N:48]2[CH:52]=[N:51][N:50]=[N:49]2)=[CH:44][C:40]=1[C:41](O)=[O:42])=[O:38]>>[CH3:36][S:37]([C:39]1[CH:47]=[CH:46][C:45]([N:48]2[CH:52]=[N:51][N:50]=[N:49]2)=[CH:44][C:40]=1[C:41]([N:27]1[CH2:28][CH2:29][C:25]([CH2:24][CH2:23][N:20]2[CH2:21][CH2:22][CH:17]([NH:16][C:8]3[N:7]([CH2:6][CH2:5][O:4][CH2:2][CH3:3])[C:11]4[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=4[N:9]=3)[CH2:18][CH2:19]2)([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH2:26]1)=[O:42])=[O:38]

Participants

3

Reactant 2

HCID 184645052-Methylsulfinyl-5-(1H-tetrazol-1-yl)benzoic AcidHCID 220090993-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-phenylpyrrolidine hydrochloric acid salt

Product 1

HCID 206422601-(2-methylsulfinyl-5-(1H-tetrazol-1-yl)benzoyl)-3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-phenylpyrrolidine

Procedure

Prepare by the method of Example 59.1 using 3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-phenylpyrrolidine hydrochloric acid salt (prepared from (−)-3-phenyl-3-(2-hydroxyethyl)pyrrolidine (R,R)-di-p-anisoyltartaric acid salt) and 2-methylsulfinyl-5-(1H-tetrazol-1-yl)benzoic acid to give the title compound.

Sources & evidence

ORD record
ord-5526878f583d4af39fc29aa9e5e908c4
Source dataset
uspto-grants-2001_04
Patent number
US06211199B1

Reaction notes

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