HRID323420

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID18464438

未命名化合物

结构：CCOCCn1c(NC2CCN(CCC3(c4ccccc4)CCNC3)CC2)nc2ccccc21.Cl

HCID22009099

未命名化合物

PRODUCTS

生成物

结构：CCOCCn1c(NC2CCN(CCC3(c4ccccc4)CCN(C(=O)c4cc(-n5nnnc5S(C)(=O)=O)ccc4OC)C3)CC2)nc2ccccc21

HCID20642248

未命名化合物

PROCEDURE

实验过程

Prepare by the method of Example 59.1 using 2-methoxy-5-(5-methylsulfonyltetrazol-1-yl)benzoic acid and 3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-phenylpyrrolidine hydrochloric acid salt (prepared from (−)-3-phenyl-3-(2-hydroxyethyl)pyrrolidine (R,R)-di-p-anisoyltartaric acid salt) to give the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-194c8ad9daf64fb0acff5b5887400110
来源数据集: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06211199B1
来源说明: uspto-grants-2001_04

反应 SMILES

[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]([N:12]2[C:16]([S:17]([CH3:20])(=[O:19])=[O:18])=[N:15][N:14]=[N:13]2)=[CH:8][C:4]=1[C:5]([OH:7])=O.Cl.[CH2:22]([O:24][CH2:25][CH2:26][N:27]1[C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=2[N:29]=[C:28]1[NH:36][CH:37]1[CH2:42][CH2:41][N:40]([CH2:43][CH2:44][C:45]2([C:50]3[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=3)[CH2:49][CH2:48][NH:47][CH2:46]2)[CH2:39][CH2:38]1)[CH3:23]>>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]([N:12]2[C:16]([S:17]([CH3:20])(=[O:19])=[O:18])=[N:15][N:14]=[N:13]2)=[CH:8][C:4]=1[C:5]([N:47]1[CH2:48][CH2:49][C:45]([CH2:44][CH2:43][N:40]2[CH2:41][CH2:42][CH:37]([NH:36][C:28]3[N:27]([CH2:26][CH2:25][O:24][CH2:22][CH3:23])[C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=4[N:29]=3)[CH2:38][CH2:39]2)([C:50]2[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=2)[CH2:46]1)=[O:7]