HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium fluoride → 1-(3,4,5-Trimethoxybenzyl)-3-(4-(trifluoromethyl)phenylmethyl)-3-(2-hydroxyethyl)-2-oxopyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium fluoride | HCID 25516 | — |
| Reactant | 1-(3,4,5-Trimethoxybenzyl)-3-(4-(trifluoromethyl)phenylmethyl)-3-(2-(t-butyldimethylsilyloxy)ethyl)-2-oxopyrrolidine | HCID 18464857 | — |
| Product | 1-(3,4,5-Trimethoxybenzyl)-3-(4-(trifluoromethyl)phenylmethyl)-3-(2-hydroxyethyl)-2-oxopyrrolidine | HCID 18465083 | — |
Reaction Steps
Prepare by the method of Example 17.4 using 1-(3,4,5-trimethoxybenzyl)-3-(4-(trifluoromethyl)phenylmethyl)-3-(2-(t-butyldimethylsilyloxy)ethyl)-2-oxopyrrolidine (0.6 g, 1.0 mmol) and ammonium fluoride (0.23 g, 6.2 mmol) to give the title compound: Rf=0.35 (silica gel, ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211199B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-0ccee9233c9f4e97a4791317edb4f4c9 |
| Source note | uspto-grants-2001_04 |