Magnesium Bromide → 2-(2,2,2-Trifluoroethoxy)ethan-1-ol

HRID 323466Notes

Reaction equation

HRID 323466 reaction equation
[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][CH2:5][CH2:6][O:7]C1CCCCO1.[Br-].[Mg+2].[Br-]>C(OCC)C>[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][CH2:5][CH2:6][OH:7]

Participants

4

Reactant 2

HCID 82241Magnesium BromideHCID 184646842-Tetrahydropyran-2-yloxyethyl 2,2,2-trifluoroethyl ether

Product 1

HCID 2558542-(2,2,2-Trifluoroethoxy)ethan-1-ol

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Combine 2-tetrahydropyran-2-yloxyethyl 2,2,2-trifluorethyl ether (2 mmol) and magnesium bromide (6 mmol) in diethyl ether (10 mL). After 24 hours, extract with water and then brine. Dry the organic layer over Na2SO4, filter, and concentrate in vacuo to give 2-hydroxyethyl 2,2,2-trifluorethyl ether.

Workup

  1. extractionextract with water
  2. dry with materialDry the organic layer over Na2SO4
  3. filtrationfilter
  4. concentrationconcentrate in vacuo

Sources & evidence

ORD record
ord-548a260dea404a5c8c1788cbebc98700
Source dataset
uspto-grants-2001_04
Patent number
US06211199B1

Reaction notes

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