Hydrochloric Acid → 1-(2-methoxy-5-(1H-tetrazol-1-yl)benzoyl)-3-(2-(4-(1-(fur-2-ylmethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-phenylpyrrolidine hydrochloric acid salt

Participants

Reaction Steps

Combine 1-(2-methoxy-5-(1H-tetrazol-1-yl)benzoyl)-3-(2-(4-(1-(fur-2-ylmethyl)-1H-benzimidazol-2-yl-amino)piperidin-1-yl)ethyl)-3-phenylpyrrolidine (0.22 g, 0.33 mmol) and methanol (4 mL). Add a solution of hydrochloric acid in dioxane (0.166 mL, 4 M, 0.62 mmol). After 18 hours, evaporate in vacuo to give a residue. Three times, combine the residue and dichloromethane and evaporate in vacuo to give a residue. Combine the residue and dichloromethane (about 2 mL) slowly add, with stirring, to diethyl ether (40 mL) to give a solid. Collect the solid by filtration and dry in vacuo to give the title compound: mp; 184-206° C.

Provenance & Evidence