反应详情

A mixture of thiourea (5.18 g, 0.068 mol) in dry MeOH (20 mL) was stirred and cooled on an ice bath. Pyridine (2 mL) was added, followed by 3-chloro-2,4-pentadione (9.15 g, 0.068 mol) dropwise. After completion of the addition the reaction mixture was allowed to warm to r. t. and stirring was continued for 4 h. The precipitates were filtered and washed with EtOAc to afford white solid 1-(2-amino-4-methyl-thiazol-5-yl)-ethanone.

1. temperaturecooled on an ice bath
2. additionAfter completion of the addition the reaction mixture
3. temperatureto warm to r
4. stirringand stirring
5. filtrationThe precipitates were filtered
6. washwashed with EtOAc