反应详情

温度

150 °C

2.06 grams (7.84 mmol) of 2-(4-fluoro-3-methyl-phenyl)-4,6-dimethylbenzyl chloride was treated with ethyldiphenylphosphinite (2.08 grams, 9.01 mmol) and heated to 150° C. for 3 hrs. After cooling to room temperature, the crude mixture was purified by silicagel chromatography ((10% acetone/90% methylene chloride) and the appropriate fractions concentrated and recrystallized from ether/hexane to provide the title compound (MP 109-111° C.).

1. temperatureAfter cooling to room temperature
2. customthe crude mixture was purified by silicagel chromatography ((10% acetone/90% methylene chloride)
3. concentrationthe appropriate fractions concentrated
4. customrecrystallized from ether/hexane