HCID 22006220, compound → HCID 22006222, compound

Participants

Reaction Steps

To a stirred solution of 3-azido-5-cyclopropyl-1-ethyl-1H-benzo[e][1,4]diazepine (5.8 g, 21.5 mmol) in ethanol (500 mL) under argon was added 10% palladium on charcoal (1.0 gm). The argon was displaced with hydrogen and the mixture was vigorously stirred for 45 min (1 atm hydrogen). The reaction was filtered and the filtrate concentrated in vacuo to an oil (5.3 gm, 100%) which solidified upon standing. MP 93-95° C.

Provenance & Evidence