Acetic Anhydride → HCID 9935016, compound

Participants

Reaction Steps

To a solution mixture containing the compound obtained in Example 1 (1 g), triethylamine (343 mg) and tetrahydrofuran (50 ml) was added acetic anhydride (254 mg) while cooling with ice. After stirring for 2 hours at room temperature, the reaction solution was concentrated under reduced pressure. The residue thus obtained was dissolved in ethyl acetate (50 ml), washed with water, dried (MgSO4) and then the solvent was distilled off to obtain the title compound (582 mg, 53%). The product was recrystallized from tetrahydrofuran. A colorless prism crystal. M.p. 266 to 267° C.

Provenance & Evidence