HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3,5-Dichloro-1-(3,3-dichloro-2-propenyloxy)-4-(3-(5-(trifluoromethyl)picolinamido)propoxy)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 5-(trifluoromethyl)pyridine-2-carboxylic Acid | HCID 10910349 | — |
| Reactant | 3-[2,6-Dichloro-4-(3,3-dichloro-allyloxy)-phenoxy]-propylamine | HCID 15869744 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 3,5-Dichloro-1-(3,3-dichloro-2-propenyloxy)-4-(3-(5-(trifluoromethyl)picolinamido)propoxy)benzene | HCID 22006843 | 10.4% |
Reaction Steps
To a mixture of 0.96 g of 4-(3-aminopropyloxy)-3,5-dichloro-1-(3,3-dichloro-2-propenyloxy)benzene, 0.53 g of 5-(trifluoromethyl)-2-pyridinecarboxylic acid, 0.37 g of triethylamine and 10 ml of chloroform was added 0.64 g of WSC hydrochloride, while stirring at room temperature. After stirring at room temperature for 6 hours, the reaction mixture was concentrated to give a residue. The residue was subjected to silica gel chromatography, which afforded 0.15 g of 3,5-dichloro-1-(3,3-dichloro-2-propenyloxy)-4-(3-(5-(trifluoromethyl)picolinamido)propoxy)benzene (10% yield), m.p., 55.1° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06214835B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-f556ffdd48454bcf8e82591ed2e2948f |
| Source note | uspto-grants-2001_04 |