反应详情

温度

0 °C

Then, 16 g of 2-ethyl-6-methylphenol was dissolved in 200 ml of chloroform, which was stirred at 0° C., and 56.6 g of tetrabutylammonium tribromide was added in small portions to this solution. After stirring at room temperature for 1 hour, the solvent was distilled out under reduced pressure. The residue was dissolved in 300 ml of diethyl ether, successively washed with 10% hydrochloric acid and water, dried over anhydrous magnesium sulfate, and then concentrated to give a crude product. The crude product was subjected to silica gel chromatography, which afforded 23 g of 4-bromo-2- ethyl-6-methylphenol (92% yield).

1. stirringAfter stirring at room temperature for 1 hour
2. distillationthe solvent was distilled out under reduced pressure
3. dissolutionThe residue was dissolved in 300 ml of diethyl ether
4. washsuccessively washed with 10% hydrochloric acid and water
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationconcentrated
7. customto give a crude product