HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 15523743, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | 3,3-Dichloro-2-oxoindoline-5-sulphonyl chloride | HCID 3022352 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 15523743 | HCID 15523743 | — |
Reaction Steps
To a solution of 5-chlorosulfonyl-3,3-dichloro-2-oxindole (100 mg, 400 umol) in methylene chloride (3 mL) was added benzylamine (135 uL, 1.2 mmol) dropwise. After stirring for 4 h. 3 N hydrochloric acid was added along with an additional volume of methylene chloride (20 mL). The organic layer was dried over magnesium sulfate, filtered, and silica gel flash chromatography (25 to 35% ethyl acetate/hexanes) yielded the title compound. ES (−) MS m/e=369 (M−H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06214858B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-28fd0c34a1de4e32a7eab91ae88204ea |
| Source note | uspto-grants-2001_04 |