Acetic Acid → HCID 22007072, compound

Participants

Reaction Steps

A mixture of 2.0 g (9.7 mmol) of 1-(1,3-benzdioxol-5-yl)pentan-2-one, 0.71 g (9.7 mmol) of n-butylamine, 2.88 g (13.6 mmol) of sodium triacetoxyborohydride and 0.58 g (9.7 mmol) of acetic acid were stirred in 1,2-dichloroethane (34 ml) under argon gas for four days at room temperature. Thereafter, the mixture was alkalized with 1 N sodium hydroxide. Water (50 ml) was added to the mixture and was extracted three times with ether (70 ml). The obtained organic phase was washed with saturated sodium chloride solution and dried over anhydrous sodium sulfate, concentrated and purified by column chromatography. Chloroform was used for eluting solvent. 1-(1,3-Benzodioxol-5-yl)-2-butylaminopentane was obtained as light yellow oil.

Provenance & Evidence