Tert-butyl (2-(2-azidoethoxy)ethyl)carbamate → tert-Butyl [2-(2-aminoethoxy)ethyl]carbamate

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Reaction Steps

A solution of tert-butyl 2-(2-azidoethoxy)ethylcarbamate (47.0 g, 0.204 mol) in MeOH was treated with 4 g of 10% Pd on carbon and shaken under H2 (3 Kg/cm2) for 24 hours. The solution was then filtered through a Celite pad and concentrated to give 35.3 g of crude tert-butyl 2-(2-aminoethoxy)ethylcarbamate as a colorless liquid that was used without further purification.

Provenance & Evidence