Hydrochloric Acid → 2-Amino-7-benzyl-1,7-dihydro-6H-purin-6-one hydrochloride

Participants

Reaction Steps

40 ml (0.34 ml) of benzyl bromide were added dropwise to a suspension of 40 g (0.147 mol) of guanosine in 200 ml of dimethyl sulfoxide and the mixture was stirred at room temperature for 4 hours. It was treated with 100 ml of concentrated hydrochloric acid and stirred at room temperature for 30 minutes. It was then poured into 1200 ml of methanol, and the precipitate was filtered off with suction and washed with methanol.

Provenance & Evidence