Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | tert-Butyl 2-bromo-2-methylpropionate | HCID 90290 | — |
| Reactant | Ethyl 2-amino-alpha-(hydroxyimino)thiazol-4-acetate | HCID 6401018 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 86299-46-9 | HCID 6242376 | — |
Reaction Steps
Ethyl (Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetate (32.25 g) of Formula (I) is dissolved in N,N-dimethylformamide (258 ml) at room temperature. Tert.-butyl 2-bromoisobutyrate (38.47 g) and anhydrous potassium carbonate (47.61 g) are added and the resulting suspension is heated to 40-45° C. for 20-25 hrs. The reaction mass is cooled to 30-32° C. and it is added slowly to water. The resulting slurry is stirred at 25-30° C. for about one and a half hours. The product is filtered, washed with water and dried under reduced pressure. Yield: 50 g (93.37%), water content <1.0% w/w; Chromatographic purity (HPLC) >98%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06214997B1 |
|---|
| Source dataset | uspto-grants-2001_04 |
|---|
| ORD ID | ord-c6aee0501c804ed8bc2d4714abc14dd8 |
|---|
| Source note | uspto-grants-2001_04 |
|---|
