Hydrogen Bromide → Methyl [2-(2-thienyl)ethylamino](2-chlorophenyl)acetate hydrobromide

関与物質

反応手順

The procedure as described in Example 9 is followed, the resulting methyl [2-(2-thienyl)ethylamino](2-chlorophenyl)acetate is dissolved in 50 ml of isopropyl acetate, to the solution 8 ml of 62% aqueous hydrogen bromide solution is added and the mixture is stirred at room temperature for 1 hour. During this time the product crystallizes. The crystals are collected, washed with 2×10 ml isopropyl acetate and dried. Weight: 32.5 g (83%) mp.: 164-165° C. The product was identified by elementary analysis, IR spectrum and 1H-NMR investigation.

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