反应详情

To 11.6 g (60.3 mmol) of ethyl benzoylacetate, was added 60 mL of a 1 N aqueous sodium hydroxide solution, and the mixture was stirred at room temperature for 16 hours. After removing organic substances by ether, the reaction solution was acidified by adding concentrated hydrochloric acid while cooling the solution in an ice bath to give a precipitate. The precipitate was collected by filtration, washed with cold water, and dried under reduced pressure. As a result, 6.56 g (40.0 mmol, 66.3%) of benzoylacetic acid was obtained as a pale yellow powder.

1. customAfter removing organic substances by ether
2. additionby adding concentrated hydrochloric acid
3. temperaturewhile cooling the solution in an ice bath
4. customto give a precipitate
5. filtrationThe precipitate was collected by filtration
6. washwashed with cold water
7. customdried under reduced pressure