Benzoyl chloride → HCID 18349809, compound

HRID 323946Notes

Reaction equation

[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]([NH:22][CH2:23][CH2:24][CH2:25][N:26]2[CH:30]=[CH:29][N:28]=[CH:27]2)([CH3:21])[CH3:20])=[CH:15][CH:14]=1>ClCCl>[N:26]1([CH2:25][CH2:24][CH2:23][NH:22][C:19]([C:16]2[CH:17]=[CH:18][C:13]([CH2:12][CH2:11][NH:10][C:1](=[O:8])[C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[CH:14][CH:15]=2)([CH3:21])[CH3:20])[CH:30]=[CH:29][N:28]=[CH:27]1

Participants

Conditions

Temperature: 0 °C

Procedure

A solution of benzoyl chloride (0.2 g) in dichloromethane (3 ml) was added dropwise to a solution of N-{1-[4-(2-aminoethyl)phenyl]-1-methylethyl}-3-(imidazol-1-yl)propylamine (0.4 g) in dichloromethane (7 ml) with stirring at 0° C. The mixture was treated in a similar manner to Example 55 to give N-[2-(4-{1-[3-(imidazol-1-yl)propylamino]-1-methylethyl}phenyl)-ethyl]benzamide as an oil.

Workup

additionThe mixture was treated in a similar manner to Example 55

Sources & evidence

ORD record: ord-46c6f3caee7043db8d44b6c2a1c2040d
Source dataset: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06215001B1

Reaction notes

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