Butyl isocyanate → HCID 18349746, compound

HRID 323947Notes

Reaction equation

HRID 323947 reaction equation
[CH2:1]([N:5]=[C:6]=[O:7])[CH2:2][CH2:3][CH3:4].[NH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]([NH:20][CH2:21][CH2:22][CH2:23][N:24]2[CH:28]=[CH:27][N:26]=[CH:25]2)([CH3:19])[CH3:18])=[CH:13][CH:12]=1>ClCCl>[CH2:1]([NH:5][C:6]([NH:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]([NH:20][CH2:21][CH2:22][CH2:23][N:24]2[CH:28]=[CH:27][N:26]=[CH:25]2)([CH3:19])[CH3:18])=[CH:13][CH:12]=1)=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 8110Butyl isocyanateHCID 18349546HCID 18349546, compound

Product 1

HCID 18349746HCID 18349746, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of butylisocyanate (0.17 g) in dichloromethane was added to a solution of N-{1-[4-(2-aminoethyl)phenyl]-1-methylethyl}-3-(imidazol-1-yl)propylamine (0.5 g) in dichloromethane (7 ml). The mixture was boiled under reflux for 30 minutes and then the solvent removed under reduced pressure. The residue was purified by flash chromatography on silica using methanol as the mobile phase to give N-butyl-N′-[2-(4-{1-[3-(imidazol-1-yl)propylamino]-1-methylethyl}phenyl)ethyl]urea as an oil.

Workup

  1. temperatureunder reflux for 30 minutes
  2. customthe solvent removed under reduced pressure
  3. customThe residue was purified by flash chromatography on silica

Sources & evidence

ORD record
ord-d4f3c0683129409ba1e34176dd53dc91
Source dataset
uspto-grants-2001_04
Patent number
US06215001B1

Reaction notes

Loading…