4-Cyanobenzoyl chloride → HCID 54323930, compound

HRID 323951Notes

Reaction equation

HRID 323951 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[N:5]=[CH:6][N:7]([CH2:9][CH2:10][CH2:11][NH:12][C:13]([CH2:22][CH3:23])([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:14][CH3:15])[CH:8]=1.[C:24]([C:26]1[CH:34]=[CH:33][C:29]([C:30](Cl)=[O:31])=[CH:28][CH:27]=1)#[N:25]>>[C:24]([C:26]1[CH:34]=[CH:33][C:29]([C:30]([NH:1][CH2:2][CH2:3][C:4]2[N:5]=[CH:6][N:7]([CH2:9][CH2:10][CH2:11][NH:12][C:13]([CH2:22][CH3:23])([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:14][CH3:15])[CH:8]=2)=[O:31])=[CH:28][CH:27]=1)#[N:25]

Participants

3

Reactant 2

HCID 801724-Cyanobenzoyl chlorideHCID 183495694-(2-Aminoethyl)-N-(1-ethyl-1-phenylpropyl)-1H-imidazole-1-propanamine

Product 1

HCID 54323930HCID 54323930, compound

Procedure

3-[4-(2-Aminoethyl)imidazol-1-yl]-N-(1-ethyl-1-phenylpropyl)propylamine (0.5 g) was reacted with 4-cyanobenzoyl chloride (0.27 g) in a similar manner to Example 55 to give 4-cyano-N-(2-{1-[3-(1-ethyl-1-phenylpropylamino)propyl]imidazol-4-yl}ethyl)benzamide, m.p. 107-109° C.

Sources & evidence

ORD record
ord-f9a80e4705b24ea79e393a8053a692b7
Source dataset
uspto-grants-2001_04
Patent number
US06215001B1

Reaction notes

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