HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 323967Generated: October 29, 2026
1,4-Dioxane → N-[1-(4-chlorophenyl)-1-methylethyl]-3-(4-formylimidazol-1-yl)propionamide
https://huagongshe.com/reaction/323967
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Benzyltrimethylammonium hydroxide | HCID 66854 | — |
| Reactant | 1H-Imidazole-4-carbaldehyde | HCID 76428 | — |
| Reactant | (-(4-Chlorophenyl)-1-methylethyl]acrylamide | HCID 86756612 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-[1-(4-chlorophenyl)-1-methylethyl]-3-(4-formylimidazol-1-yl)propionamide | HCID 18349775 | — |
Reaction Steps
A mixture of N-[(-(4-chlorophenyl)-1-methylethyl]acrylamide (22.35 g), imidazole-4-carboxaldehyde (9.6 g), benzyltrimethylammonium hydroxide (2.24 ml of a 40% solution in methanol, Triton®B) and 1,4-dioxane (112 ml) was stirred and heated at 95° C. for 6 hours and then worked up as described in Example 19a to give N-[1-(4-chlorophenyl)-1-methylethyl]-3-(4-formylimidazol-1-yl) propionamide, m.p. 151-153° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06215001B1 |
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| Source dataset | uspto-grants-2001_04 |
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| ORD ID | ord-d2baa66292a54d9494fb733582632ea5 |
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| Source note | uspto-grants-2001_04 |
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