3-Chloro-1H-indole-6-carboxylic acid → 4-{(R)-2-[(3-Chloro-1H-indole-6-carbonyl)amino]-2-phenyl-ethoxymethyl}piperidine-1-carboxylic acid tert-butyl ester

Participants

Reaction Steps

Using coupling method A, 4-[(R)-2-amino-2-phenylethoxy-methyl]piperidine-1-carboxylic acid tert-butyl ester (3 g, 9.0 mmol) and 3-chloroindole-6-carboxylic acid (1.7 g, 9.0 mmol) afforded the title compound as a crude residue, which was used without further purification.

Provenance & Evidence