Imidazole → HCID 54093048, compound

HRID 323987Notes

Reaction equation

HRID 323987 reaction equation
[C:1]([CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([NH:13][C:14](=[O:17])[CH:15]=[CH2:16])([CH3:12])[CH3:11])=[CH:6][CH:5]=1)#[N:2].[NH:18]1[CH:22]=[CH:21][N:20]=[CH:19]1.[OH-].C([N+](C)(C)C)C1C=CC=CC=1>O1CCOCC1>[C:1]([CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([NH:13][C:14](=[O:17])[CH2:15][CH2:16][N:18]2[CH:22]=[CH:21][N:20]=[CH:19]2)([CH3:12])[CH3:11])=[CH:6][CH:5]=1)#[N:2]

Participants

5

Reactant 3

HCID 795ImidazoleHCID 66854Benzyltrimethylammonium hydroxideHCID 18349629HCID 18349629, compound

Product 1

HCID 54093048HCID 54093048, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of N-{1-[4-(cyanomethyl)phenyl]-1-methylethyl}acrylamide (20.5 g), imidazole (6.11 g), benzyltrimethylammonium hydroxide (74 mg) and 1,4-dioxane (300 ml) gave N-{1-[4-(cyanomethyl)phenyl]-1-methylethyl}-3-(imidazol-1-yl)propionamide as an oil.

Sources & evidence

ORD record
ord-e4c89680aed84c3e95ebba0759e029d8
Source dataset
uspto-grants-2001_04
Patent number
US06215001B1

Reaction notes

Loading…