HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-1H-indole-6-carboxylic acid → 4-{2-[(3-Chloro-1H-indole-6-carbonyl)amino]-2-cyclopentyl-ethoxymethyl}piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-1H-indole-6-carboxylic acid | HCID 15543042 | — |
| Reactant | 4-(2-Amino-2-cyclopentyl-ethoxymethyl)piperidine-1-carboxylic acid tert-butyl ester | HCID 69313045 | — |
| Product | 4-{2-[(3-Chloro-1H-indole-6-carbonyl)amino]-2-cyclopentyl-ethoxymethyl}piperidine-1-carboxylic acid tert-butyl ester | HCID 69307866 | — |
Reaction Steps
Using coupling method A, 4-(2-amino-2-cyclopentyl-ethoxymethyl)piperidine-1-carboxylic acid tert-butyl ester (460 mg, 1.4 mmol) and 3-chloroindole-6-carboxylic acid (275 mg, 1.4 mmol) afforded, after purification (SiO2: 40% EtOAc in hexane), 211 mg (30%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427632B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-1ad637322827475abe3124466e52e92f |
| Source note | uspto-grants-2008_09 |