HuagongsheHuagongshe Chemistry Print Report · For research reference only
Anisole → 3-Methyl-N-[(R)-1-phenyl-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Anisole | HCID 7519 | — |
| Reactant | 4-{(R)-2-[(3-Methyl-1H-indole-6-carbonyl)amino]-2-phenyl-ethoxymethyl}piperidine-1-carboxylic acid tert-butyl ester | HCID 69310616 | — |
| Product | 3-Methyl-N-[(R)-1-phenyl-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide | HCID 69307977 | — |
Reaction Steps
Using deprotection method B, but without addition of anisole, 4-{(R)-2-[(3-methyl-1H-indole-6-carbonyl)amino]-2phenylethoxymethyl}piperidine-1-carboxylic acid tert-butyl ester (1.5 g crude, 3.0 mmol) afforded the title compound as a crude residue, which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427632B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-80b2e9382af14681ba9c451937d0cb25 |
| Source note | uspto-grants-2008_09 |