Potassium Bromide → 2-Hydroxy-4-[5'-(8-phenyl-octylcarbamoyl)-3,3''-bis-trifluoromethyl-[1,1':3',1'']terphenyl-2'-yloxysulfonyl]-benzoic acid

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Reaction Steps

The title compound was prepared as an white foam (0.541 g, 78%) from 2′-Hydroxy-3,3″-bis-trifluoromethyl-[1,1′:3′1″]terphenyl-5′-carboxylic acid (8-phenyl-octyl)-amide and 4-chlorosulfonyl-2-hydroxy-benzoic acid using a procedure similar to step 3 of Example 179. 1H NMR (DMSO-d6) δ11.60 (bs, 2H); 8.70 (t, 1H); 7.94 (s, 2H); 7. 88-7.80 (m, 4H); 7.69-7.57 (m, 5H); 7.26-7.10 (m, 5H); 6.68 (dd, 1H); 6.57 (d, 1H); 3.25 (dd, 2H); 2.52 (t, 2H); 1.53 (m, 4H); 1.28 (m, 8H); IR (KBr) 3400, 2950, 2840, 1690, 1640, 1600, 1550, 1460, 1380, 1320, 1280, 1200, 1170, 1120, 1080 cm−1; mass spectrum [(−)ESI], m/z 812 (M−H)−; Anal. Calcd. for C42H37F6NO7S: C, 61.99; H, 4.58; N, 1.72, Found: C, 61.40; H, 4.80; N, 1.68.

Provenance & Evidence