HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 3-Chloro-N-[(R)-1-phenyl-2-(1-isopropylpiperidin-4-yl-methoxy)ethyl]-1H-indole-6-carboxamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | HCID 9866338 | HCID 9866338 | — |
| Product | 3-Chloro-N-[(R)-1-phenyl-2-(1-isopropylpiperidin-4-yl-methoxy)ethyl]-1H-indole-6-carboxamide hydrochloride | HCID 69310810 | — |
Reaction Steps
Using alkylation method A, 3-chloro-N-[(R)-1-phenyl-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide (200 mg, 0.45 mmol) and acetone (0.33 mL, 4.5 mmol) afforded, after purification (SiO2: 8:2:1 hexane:EtOAc:isopropylamine) and conversion to the HCl salt by general method B, 120 mg (55%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427632B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-8732b08ab144473298fa65faa65bf153 |
| Source note | uspto-grants-2008_09 |