HCID 12967234, compound → HCID 11076774, compound

Participants

Reaction Steps

In nitrogen atmosphere at a room temperature, 9.9 g of Celite and 4.61 g (16.5 mmol) of 1-(3-methoxybenzyloxy)-2,2,4,4-tetramethyl-3-pentanol (Compound [48]) were added to 75 ml of dichloromethane and the mixture was stirred. After adding 4.26 g (19.7 mmol) of PCC and stirring for 7 hours, 800 mg (3.71 mmol) of PCC was added and then the reaction mixture was stirred over night. Adding ether to the reaction mixture, the resulting mixture was filtrated by Celite and the filtrate was concentrated. The concentrate was applied to a silica gel column and the elution was carried out with the mixture of hexane and ethyl acetate (hexane:ethyl acetate=10:1) to obtain 4.32 g of 1-(3-methoxybenzyloxy)-2,2,4,4-tetramethyl-3-pentanon (Compound [49]) as a colorless compound. Yield 94.4%.

Provenance & Evidence