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HRID32420

反应详情

EQUATION

反应方程式

HRID 32420 的结构方程式

REACTANTS

反应物

2
结构：CCOC1(O[Si](C)(C)C)CC1
HCID2734686

(1-Ethoxycyclopropoxy)trimethylsilane

C8H18O2Si

结构：Cl.O=C(N[C@@H](COCC1CCNCC1)c1ccccc1)c1ccc2c(Cl)c[nH]c2c1
HCID69307898

未命名化合物

PRODUCTS

生成物

1
结构：Cl.O=C(N[C@@H](COCC1CCN(C2CC2)CC1)c1ccccc1)c1ccc2c(Cl)c[nH]c2c1
HCID69309671

未命名化合物

PROCEDURE

实验过程

Using alkylation method A with addition of 3A molecular sieves, 3-chloro-N-[(R)-1-phenyl-2-(piperidin-4-ylmethoxy)-ethyl]-1H-indole-6-carboxamide hydrochloride (200 mg, 0.44 mmol) and [(1-ethoxycyclopropyl)oxy]trimethylsilane (0.53 mL, 2.7 mmol) afforded, after purification (SiO2: 0 to 5% isopropylamine in 10:2:2:DCM:EtOAc:hexane) and after conversion to the HCl salt by general method B, 80 mg (40%) of the title compound.

WORKUP

后处理

  1. customafforded
  2. customafter purification (SiO2: 0 to 5% isopropylamine in 10:2:2:DCM:EtOAc:hexane)