Hydrogen Bromide → HCID 22004117, compound

Participants

Reaction Steps

Demethylation of 4-methoxy-1-phenylbenzimidazole hydrochloride with HBr in glacial acetic acid as described for synthesis of Example 2 gave Example 11 as the HCl salt, (77%): mp (MeOH/Et2O) 238-240° C. 1H NMR (D2O):δ9.41 (s, 1 H, H-2), 7.74-7.67 (m, 5 H, Ph), 7.47 (dd, J=8.3, 8.2 Hz, 1 H, H-6), 7.22 (d, J=8.3 Hz, 1 H, H-7), 7.08 (dd, J=8.2 Hz, 1 H, H-5); 13C NMR:δ147.45 (s), 141.70 (d), 136.00 (s), 135.85 (s), 133.32 (d), 133.10 (d), 131.01 (d), 127.47 (d), 123.81 (s), 114.17 (d), 106.90 (d).

Provenance & Evidence