Acetone → HCID 44444070, compound

HRID 32433Notes

Reaction equation

HRID 32433 reaction equation
[Cl:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([NH:13][CH:14]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[F:30])[CH2:15][O:16][CH2:17][CH:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)=[O:12])=[CH:8][CH:9]=2)[NH:4][CH:3]=1.[CH3:31][C:32]([CH3:34])=O>>[Cl:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([NH:13][CH:14]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[F:30])[CH2:15][O:16][CH2:17][CH:18]3[CH2:23][CH2:22][N:21]([CH:32]([CH3:34])[CH3:31])[CH2:20][CH2:19]3)=[O:12])=[CH:8][CH:9]=2)[NH:4][CH:3]=1

Participants

3

Reactant 2

HCID 180AcetoneHCID 69310707HCID 69310707, compound

Product 1

HCID 44444070HCID 44444070, compoundYield 78%

Procedure

Using alkylation method A, 3-chloro-N-[1-(2-fluoro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide (303 mg, 0.71 mmol) and acetone (2 mL, 27 mmol) afforded 260 mg (78%) of the title compound.

Sources & evidence

ORD record
ord-75c89a1f0fd449389cd5688723457621
Source dataset
uspto-grants-2008_09
Patent number
US07427632B2

Reaction notes

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