HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 324346Generated: October 29, 2026
Acetic Acid → 4-(3-Chloro-4-methoxybenzyl)amino-6-cyano-1(2H)-phthalazinone
https://huagongshe.com/reaction/324346
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-Chloro-4-((3-chloro-4-methoxybenzyl)amino)-6-phthalazinecarbonitrile | HCID 10451065 | — |
| Solvent | N-Methyl-2-piperidone | HCID 13603 | — |
| Product | 4-(3-Chloro-4-methoxybenzyl)amino-6-cyano-1(2H)-phthalazinone | HCID 15524302 | — |
Reaction Steps
1-Chloro-4-(3-chloro-4-methoxybenzyl)amino-6-cyanophthalazine (1.0 g) prepared in Example 1 was dissolved in 10 ml of N-methyl-2-piperidone, followed by the addition of 0.26 ml of acetic acid and 2.1 ml of diisopropylethylamine. The obtained mixture was stirred at 170° C. for 7 hours, followed by the addition of 100 ml of water. The crystals thus precipitated were recovered by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06218392B1 |
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| Source dataset | uspto-grants-2001_04 |
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| ORD ID | ord-445c79fa8ee548ceb624ed8cc7016ed2 |
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| Source note | uspto-grants-2001_04 |
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