Phosphorus oxychloride → HCID 15521236, compound

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Reaction Steps

A mixture of 3-methylsulfanyl-6-methyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-4-ol (3.700 g, 9.85 mmol) and phosphorous oxychloride (18.115 g, 11 ml) was heated at reflux for 4 hours. The mixture was cooled and poured over ice-water and stirred for 10 minutes. Precipitate formed and was filtered to give a brown solid. The brown solid was pumped in vacuo to give 3.718 g (96% yield). 1H NMR (CDCl3): 2.65(s,3H),2.7(s,3H), 7.5(s,2H)ppm.

Provenance & Evidence