Acetone → HCID 69307914, compound

HRID 32438Notes

Reaction equation

HRID 32438 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:18][C:19]([C:21]2[CH:29]=[C:28]3[C:24]([CH:25]=[CH:26][NH:27]3)=[CH:23][CH:22]=2)=[O:20])[CH2:9][O:10][CH2:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[CH:4][CH:3]=1.[CH3:30][C:31]([CH3:33])=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:18][C:19]([C:21]2[CH:29]=[C:28]3[C:24]([CH:25]=[CH:26][NH:27]3)=[CH:23][CH:22]=2)=[O:20])[CH2:9][O:10][CH2:11][CH:12]2[CH2:13][CH2:14][N:15]([CH:31]([CH3:33])[CH3:30])[CH2:16][CH2:17]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 180AcetoneHCID 69313093HCID 69313093, compound

Product 1

HCID 69307914HCID 69307914, compound

Procedure

Using alkylation method A, N-[1-(4-fluorophenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide (900 mg, 2.3 mmol) and acetone (25 mL, 340 mmol) afforded, after purification (SiO2: 8:2:1 hexane:EtOAc:isopropylamine), 45 mg (5%) of the title compound.

Workup

  1. customafforded
  2. customafter purification (SiO2: 8:2:1 hexane:EtOAc:isopropylamine), 45 mg (5%) of the title compound

Sources & evidence

ORD record
ord-69a75afd744048cc9e1fb4d3a6990082
Source dataset
uspto-grants-2008_09
Patent number
US07427632B2

Reaction notes

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