Cyclohexyl isocyanate → HCID 20637943, compound

HRID 324388Notes

Reaction equation

HRID 324388 reaction equation
[C:1]1([C@H:7]2[C:12]3[NH:13][C:14]4[C:19]([C:11]=3[CH2:10][C@H:9]([C:20](OC)=[O:21])[NH:8]2)=[CH:18][CH:17]=[CH:16][CH:15]=4)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:24]1([N:30]=[C:31]=[O:32])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>>[CH:24]1([N:30]2[C:20](=[O:21])[C@H:9]3[N:8]([C@@H:7]([C:1]4[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=4)[C:12]4[NH:13][C:14]5[CH:15]=[CH:16][CH:17]=[CH:18][C:19]=5[C:11]=4[CH2:10]3)[C:31]2=[O:32])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 18502Cyclohexyl isocyanateHCID 736465HCID 736465, compound

Product 1

HCID 20637943HCID 20637943, compound

Procedure

The same method as employed in the preparation of Example 1 but starting from trans methyl 1,2,3,4-tetrahydro-1-phenyl-9H-pyrido[3,4-b]indole-3-carboxylate and cyclohexyl isocyanate gave after recrystallisation from methanol, the title compound as white crystals m.p.: 248-250° C.

Workup

  1. customThe same method as employed in the preparation of Example 1
  2. customgave
  3. customafter recrystallisation from methanol

Sources & evidence

ORD record
ord-ed6eb099ab6d466c93526c96ee28816b
Source dataset
uspto-grants-2001_04
Patent number
US06218400B1

Reaction notes

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