Methyl iodide → HCID 70113590, compound

Participants

Reaction Steps

Sodium hydride (60% dispersion by wt) (112 mg) was added to a stirred solution of the product from step (v) (1.0 g) in N,N-dimethylformamide (20 ml) at room temperature. After 0.75 h, methyl iodide (0.175 ml) was added and stirring continued for 1 h. The mixture was quenched with water and extracted with ethyl acetate. The organic phase was washed with water, dried (MgSO4) and evaporated under reduced pressure. Purification was by chromatography eluting with 5% methanol in dichloromethane.

Provenance & Evidence