Lawesson's reagent → HCID 22003619, compound

HRID 324439Notes

Reaction equation

HRID 324439 reaction equation
[CH3:1][N:2]1[CH:7]=[C:6]([CH:8]2[C:18]3[C:13](=[N:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11][C:10]3[CH:19]=[C:20]([CH3:23])[CH:21]=[CH:22][C:9]2=3)[C:5](=O)[NH:4][C:3]1=[O:25].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:35])=CC=1>>[CH3:1][N:2]1[CH:7]=[C:6]([CH:8]2[C:18]3[C:13](=[N:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11][C:10]3[CH:19]=[C:20]([CH3:23])[CH:21]=[CH:22][C:9]2=3)[C:5](=[S:35])[NH:4][C:3]1=[O:25]

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 22003666HCID 22003666, compound

Product 1

HCID 22003619HCID 22003619, compound

Procedure

The title compound was prepared from the product of step (i) (0.2 g) and Lawesson's reagent (0.29 g) according to the method of example 2 step (ii). Purification was by chromatography eluting with 50% acetone in isohexane followed by trituration with isohexane/ethyl acetate.

Workup

  1. customPurification
  2. washeluting with 50% acetone in isohexane

Sources & evidence

ORD record
ord-2854235c50fa4b28a06465bce85885fd
Source dataset
uspto-grants-2001_04
Patent number
US06218376B1

Reaction notes

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