HCID 131722520, compound → 5-[2-(3-Chlorophenyl)ethyl]-2-methyloxazole-4-carboxylic acid, ethyl ester

Participants

Reaction Steps

Thionyl chloride (180 ml) was added to the product of step (iii) (45.5 g) at 0° C. The mixture was stirred at room temperature for 2 hours and heated at reflux for 40 min. The residue after evaporation under reduced pressure was dissolved in ethyl acetate and washed with saturated sodium bicarbonate solution. The organic phase was dried (MgSO4) and solvent evaporated under reduced pressure. Purification was by chromatography eluting with 1-2% ethanol in dichloromethane to give the subtitle product as an orange oil.

Provenance & Evidence