Potassium Hydroxide → HCID 22003647, compound

HRID 324445Notes

Reaction equation

HRID 324445 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][C:10]2[O:14][C:13]([CH3:15])=[N:12][C:11]=2[C:16]([O:18]CC)=[O:17])[CH:5]=[CH:6][CH:7]=1.[OH-].[K+]>C(O)C.O>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][C:10]2[O:14][C:13]([CH3:15])=[N:12][C:11]=2[C:16]([OH:18])=[O:17])[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 1317225215-[2-(3-Chlorophenyl)ethyl]-2-methyloxazole-4-carboxylic acid, ethyl ester

Product 1

HCID 22003647HCID 22003647, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of the product from step (iv) (24.36 g) and potassium hydroxide (9 g) in ethanol (250 ml) and water (20 ml) was stirred at room temperature for 4 hours and concentrated under reduced pressure. The residue was suspended in water, acidified with 2N HCl and extracted with ethyl acetate. The combined extracts were washed with water and saturated brine. The organic layer was collected, dried (MgSO4) and solvent evaporated to give the subtitle product.

Workup

  1. concentrationconcentrated under reduced pressure
  2. extractionextracted with ethyl acetate
  3. washThe combined extracts were washed with water and saturated brine
  4. customThe organic layer was collected
  5. dry with materialdried (MgSO4) and solvent
  6. customevaporated

Sources & evidence

ORD record
ord-92a035dfa8074c4da7438e5bc4590d3a
Source dataset
uspto-grants-2001_04
Patent number
US06218376B1

Reaction notes

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