(+/-)-5-(9,10-Dihydro-4-hydroxy-2-methyl-4H-benzo[5,6]cyclohepta[1,2-d]oxazol-4-yl)-1-methyl-2,4(1H,3H)-pyrimidinedione → HCID 70112978, compound

Participants

Reaction Steps

A stirred solution of the product from step (ii) (280 mg) in trifluoroacetic acid (5 ml), was heated under reflux for 96 h and evaporated. The residue was slurried in toluene and evaporated (twice). Purification was by flash chromatography eluting 50% acetone in isohexane, followed by a second column eluting with 4% ethanol in dichloromethane to give a yellow solid. Yield 75 mg. Used directly in the next step.

Provenance & Evidence