Sodium Nitrite → HCID 178472911, compound

HRID 324458Notes

Reaction equation

HRID 324458 reaction equation
[N:1]([O-:3])=O.[Na+].[CH2:5]([C:7]1[CH:8]=[C:9]([CH2:13][CH2:14][C:15](=[O:22])[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:10]=[CH:11][CH:12]=1)[CH3:6]>O.C(O)(=O)C>[CH2:5]([C:7]1[CH:8]=[C:9]([CH2:13][CH2:14][C:15](=[O:22])[C:16](=[N:1][OH:3])[C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:10]=[CH:11][CH:12]=1)[CH3:6]

Participants

5

Reactant 2

HCID 23668193Sodium NitriteHCID 1317225225-(3-Ethylphenyl)-3-oxopentanoic acid, ethyl ester

Product 1

HCID 178472911HCID 178472911, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent2×

Procedure

A solution of sodium nitrite (6.3 g) in water (10 ml) was added to a stirred solution of the product from step (iii) (20.6 g) in acetic acid (30 ml) at <30° C. The reaction mixture was stirred at room temperature for 18 hours. Water (150 ml) was added and the mixture was stirred for 2 hours and extracted with diethyl ether. The combined extracts were washed with water and saturated aqueous sodium bicarbonate solution. The organic phase was collected, dried (MgSO4) and solvent evaporated under reduced pressure.

Workup

  1. stirringthe mixture was stirred for 2 hours
  2. extractionextracted with diethyl ether
  3. washThe combined extracts were washed with water and saturated aqueous sodium bicarbonate solution
  4. customThe organic phase was collected
  5. dry with materialdried (MgSO4) and solvent
  6. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-acd48cc5ac994227898a8abe02ba9f10
Source dataset
uspto-grants-2001_04
Patent number
US06218376B1

Reaction notes

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