Acetone → Benzyl N-[(R)-1-(Isopropyl)-2-(1-isopropylpiperidin-4-yl-methoxy)ethyl]carbamate

HRID 32446Notes

Reaction equation

[CH:1]([C@@H:4]([NH:14][C:15](=[O:24])[O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:5][O:6][CH2:7][CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)([CH3:3])[CH3:2].[CH3:25][C:26]([CH3:28])=O>>[CH:1]([C@@H:4]([NH:14][C:15](=[O:24])[O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:5][O:6][CH2:7][CH:8]1[CH2:13][CH2:12][N:11]([CH:26]([CH3:28])[CH3:25])[CH2:10][CH2:9]1)([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 180Acetone

HCID 69308099HCID 69308099, compound

Product 1

HCID 69307909Benzyl N-[(R)-1-(Isopropyl)-2-(1-isopropylpiperidin-4-yl-methoxy)ethyl]carbamateYield 92%

Procedure

Using alkylation method A, benzyl N-[(R)-1-(isopropyl)-2-(piperidin-4-ylmethoxy)ethyl]carbamate (1.1 g, 3.2 mmol) and acetone (5 mL, 68 mmol) afforded 1.1 g (92%) of the title compound.

Sources & evidence

ORD record: ord-d7dfc55b5b814184ab884a00aea6681c
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07427632B2

Reaction notes

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