huagongshe.com
HRID32447

反应详情

EQUATION

反应方程式

HRID 32447 的结构方程式

REACTANTS

反应物

2
结构：COc1ccc(C(=O)Cl)cc1
HCID7477

Benzoyl chloride, 4-methoxy-

C8H7ClO2

结构：CC(C)N1CCC(COC[C@H](N)c2ccccc2)CC1
HCID69309716

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(C(=O)N[C@@H](COCC2CCN(C(C)C)CC2)c2ccccc2)cc1.Cl
HCID69310552

未命名化合物

PROCEDURE

实验过程

Using coupling method B, (R)-2-(1-isopropylpiperidin-4-ylmethoxy)-1-phenylethylamine (150 mg, 0.54 mmol) and 4-methoxybenzoyl chloride (0.12 mL, 1.0 mmol) afforded, after purification (SiO2: 4:2:1 DCM:EtOAc:isopropyl-amine) and conversion to the HCl salt by general method A, 205 mg (91%) of the title compound.

WORKUP

后处理

  1. customafforded
  2. customafter purification (SiO2: 4:2:1 DCM:EtOAc:isopropyl-amine) and conversion to the HCl salt by general method A, 205 mg (91%) of the title compound