Lawesson's reagent → HCID 178432332, compound

HRID 324473Notes

Reaction equation

HRID 324473 reaction equation
[CH3:1][N:2]1[CH:7]=[C:6]([CH:8]2[C:14]3[N:15]=[C:16]([CH3:18])[NH:17][C:13]=3[CH:12]=[CH:11][C:10]3[CH:19]=[CH:20][CH:21]=[CH:22][C:9]2=3)[C:5](=O)[NH:4][C:3]1=[O:24].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:34])=CC=1>>[CH3:1][N:2]1[CH:7]=[C:6]([CH:8]2[C:14]3[N:15]=[C:16]([CH3:18])[NH:17][C:13]=3[CH:12]=[CH:11][C:10]3[CH:19]=[CH:20][CH:21]=[CH:22][C:9]2=3)[C:5](=[S:34])[NH:4][C:3]1=[O:24]

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 178432331HCID 178432331, compound

Product 1

HCID 178432332HCID 178432332, compound

Procedure

The title product was prepared from the product of step (iv) (0.1 g) and Lawesson's reagent (0.378 g) according to the method of example 34 step (iv). Purification was by chromatography eluting with 0-5% methanol in dichloromethane followed by reverse phase HPLC using a 40 mm Novapak column eluting with 15-85% methanol in 0.1% aqueous ammonium acetate gradient over 9 min.

Workup

  1. customPurification
  2. washeluting with 0-5% methanol in dichloromethane
  3. washeluting with 15-85% methanol in 0.1% aqueous ammonium acetate gradient over 9 min.

Sources & evidence

ORD record
ord-3ae2a5d1a6034d569fe816fd86565124
Source dataset
uspto-grants-2001_04
Patent number
US06218376B1

Reaction notes

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