Sodium borohydride → HCID 70110715, compound

HRID 324475Notes

Reaction equation

HRID 324475 reaction equation
[BH4-].[Na+].[Cl:3][C:4]1[CH:5]=[CH:6][C:7]2[C:17](=[O:18])[C:12]3[N:13]=[C:14]([CH3:16])[S:15][C:11]=3[CH:10]=[CH:9][C:8]=2[CH:19]=1>CO.ClCCl>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]2[CH:17]([OH:18])[C:12]3[N:13]=[C:14]([CH3:16])[S:15][C:11]=3[CH:10]=[CH:9][C:8]=2[CH:19]=1

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 22003670HCID 22003670, compound

Product 1

HCID 70110715HCID 70110715, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

Sodium borohydride (0.3 g) was added portionwaise to a suspension of the product from step (ii) (1 g) in a mixture of methanol (40 ml) and dichloromethane (30 ml) at room temperature. After 1 hour the reaction mixture was partitioned between dichloromethane and brine. The organic phase was collected, dried (MgSO4) and evaporated under reduced pressure to leave a beige foam. Yield: 1 g. Used directly in the next step.

Workup

  1. customAfter 1 hour the reaction mixture was partitioned between dichloromethane and brine
  2. customThe organic phase was collected
  3. dry with materialdried (MgSO4)
  4. customevaporated under reduced pressure
  5. customto leave a beige foam

Sources & evidence

ORD record
ord-47e158777f3844e59057d015886848eb
Source dataset
uspto-grants-2001_04
Patent number
US06218376B1

Reaction notes

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