Sodium borohydride → (+/-)-7-Chloro-1-((imidazol-4-yl)ethyl)-2-methyl-4h-benzo[5,6]cyclohepta[1,2-d]imidazol-4-ol

HRID 324479Notes

Reaction equation

HRID 324479 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:22](=[O:23])[C:10]3[N:11]=[C:12]([CH3:21])[N:13]([CH2:14][CH2:15][C:16]4[N:17]=[CH:18][NH:19][CH:20]=4)[C:9]=3[CH:8]=[CH:7][C:6]=2[CH:24]=1.[BH4-].[Na+]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:22]([OH:23])[C:10]3[N:11]=[C:12]([CH3:21])[N:13]([CH2:14][CH2:15][C:16]4[N:17]=[CH:18][NH:19][CH:20]=4)[C:9]=3[CH:8]=[CH:7][C:6]=2[CH:24]=1

Participants

3

Reactant 2

HCID 4311764Sodium borohydrideHCID 178432358HCID 178432358, compound

Product 1

HCID 178432308(+/-)-7-Chloro-1-((imidazol-4-yl)ethyl)-2-methyl-4h-benzo[5,6]cyclohepta[1,2-d]imidazol-4-ol

Procedure

The subtitle product was prepared from the product of step (i) (0.966 g) and sodium borohydride (0.215 g) according the method of example 71 step (ii). Used directly in the next step.

Sources & evidence

ORD record
ord-f6fa800f083b412d93a0f287b6315d8a
Source dataset
uspto-grants-2001_04
Patent number
US06218376B1

Reaction notes

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