反应详情

温度

100 °C

A mixture of the product from step (iv) (0.535 g), and phosphorus pentasulphide (0.967 g) in 1,4-dioxane (10 ml) was heated at 100° C. for 3 h. The solvent evaporated and the residue dissolved in dichloromethane, washed with saturated aqueous sodium bicarbonate solution then with water, dried (MgSO4) and evaporated. Purification was by chromatography on a biotage silica column, using 3% methanol/0.1% 0.880 ammonia in dichloromethane as eluant.

1. customThe solvent evaporated
2. dissolutionthe residue dissolved in dichloromethane
3. washwashed with saturated aqueous sodium bicarbonate solution
4. dry with materialwith water, dried (MgSO4)
5. customevaporated
6. customPurification