HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 3-Chloro-N-[(R)-1-phenyl-2-[2-(1-methylpiperidin-4-yl)-ethoxy]ethyl]-1H-indole-6-carboxamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | HCID 69309604 | HCID 69309604 | — |
| Product | 3-Chloro-N-[(R)-1-phenyl-2-[2-(1-methylpiperidin-4-yl)-ethoxy]ethyl]-1H-indole-6-carboxamide hydrochloride | HCID 69313184 | 137.6% |
Reaction Steps
Using alkylation method B, 3-chloro-N-[(R)-1-phenyl-2-[2-(piperidin-4-yl)ethoxy]ethyl]-1H-indole-6-carboxamide hydrochloride (300 mg, 0.65 mmol) and paraformaldehyde (195 mg, 6.5 mmol) afforded 213 mg (75%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07427632B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-50fd19aeef6c4b42a91184c0a3782547 |
| Source note | uspto-grants-2008_09 |